台大心理系

系所成員 系所師資 專任教授 蔡立慧 Tsai, Li-Huei

蔡立慧 Tsai, Li-Huei

  • 職稱: 特聘研究講座
  • 研究領域: 生物心理學
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  • 辦公室/電話: .
  • 經歷:

    Assistant Professor at Department of Pathology, Harvard Medical School (1994-1999)
    Associate Professor at Department of Pathology, Harvard Medical School (1999-2002)
    Assistant Investigator, Howard Hughes Medical Institute (1997-2002)
    Professor at Department of Pathology, Harvard Medical School (2002-2006)
    Investigator, Howard Hughes Medical Institute (2002-2013)
    Picower Professor of Neuroscience, Massachusetts Institute of Technology (2006-)
    Investigator, Riken-MIT Neuroscience Research Center (2006-2007)
    Associate Member, Broad Institute (2006-2009)
    Director, Neurobiology Program, Stanley Center for Psychiatric Research (2007-2011)
    Director, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences at Massachusetts Institute of Technology (2009-)

  • 學術榮譽:

    Leukemia Society of America Special Fellowship (1992-1995)
    Milton Fund Award (1994)
    Hurst Fund Award (1995)
    Rita Allen Scholarship (1996-2001)
    Klingenstein Fellowship in the Neurosciences (1997-2000)
    Young Investigator Award, Metropolitan Life Foundation (2001)
    Alzheimer's Association (2002-2005)
    Outstanding Contributor Award, Alzheimer Research Forum (2004)
    Alzheimer's Research Consortium (2003-2006)
    Changjiang Scholar (2008)
    Simons Foundation Autism Research Initiative Award (2008-2011)
    Fellow, American Association for the Advancement of Science (AAAS) (2008)
    NIH Cantoni Lecture Award (2009)
    Glenn Award for Research in Biological Mechanisms of Aging (2010)
    Member, U.S. Institute of Medicine of NAS (2011)

  • 學歷:

    D.V.M. National Chung Hsing University (1983)
    M.S. University of Wisconsin (1986)
    Ph.D. University of Texas Southwestern Medical Center (1990)
    Postdoctoral Fellow with Ed Harlow at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY and Massachusetts General Hospital Cancer Center (1990-94)

Publications

Publications

2015

Gjoneska E, Pfenning A, Mathys H, Quon G, Kundage A, Tsai LH**, Kellis M**, Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease. Nature 2015 Feb 18; doi: 10.1038/nature14252. (**Co-Contributing Authors).

2014

Gräff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, Rei D, Bero AW, Phan TX, Wagner F, Holson E, Xu J, Sun, J, Neve RL, Mach RH, Haggarty SJ, Tsai LH. Cell 2014 Jan 16;156(1-2):261-76. doi: 10.1016/j.cell.2013.12.020. PMID: 24439381.

Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Molecular Psychiatry. 2014 Nov doi: 10.1038/mp.2014.143 PMID: 25403839.

Seo J, Giusti-Rodríguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madabhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH. Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment. Cell 2014 Apr 10;157(2):486-98.doi:10.10.16/j.cell.2014.01.065. PMID:24725413.

Durak O, de Anda FC, Singh KK, Leussis MP, Petryshen TL, Sklar P, Tsai LH. Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin. Mol Psychiatry. 2014 May 13 doi: 10.1038/mp.2014.42. [Epub ahead of print]. PMID:24821222.

Rudenko A, Tsai LH. Epigenetic modifications in the nervous system and their impact upon cognitive impairments. Neuropharmacology. 2014 May; 80:70-82. doi: 10.1016/j.neuropharm.2014.01.043. Epub 2014 Feb 1. PMID:24495398.

Tsai LH, Madabhushi R. Alzheimer’s disease: A protective factor for the ageing brain. Nature 2014 Mar 27;507(7493):439-40. doi: 10.1038/nature13214. PMID: 24670758.

2013

Rudenko A, Dawlaty M, Seo J, Cheng A, Meng J, Le T, Faull K, Jaenisch R, Tsai LH. “Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction.” Neuron 79.6 (2013): 1109-1122. ScienceDirect. Web. 18 Sept. 2013.

Wang W, Pan L, Su S, Quinn E, Sasaki M, Jimenez J, Mackenzie I, Huang E, Tsai LH. Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons. Nature 2013 September 15; doi:10.1038/nn.3514(Online).

2012

Gräff J, Rei D, Guan J, Wang W, Seo J, Henning K, Nieland T, Fass D, Kao P, Kahn M, Su S, Samiei A, Joseph N, Haggarty S, Delalle I, Tsai LH. An epigenetic blockade of cognitive functions in the neurodegeneration brain. Nature 2012 Feb 29;483(7388):222-6. doi: 10.1038/nature10849 (PMC Journal- In Process).

Kosik KS, Rapp PR, Raz N, Small SA, Sweatt JD, Tsai LH. Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Epigenetics. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(7):741-6. (PMC Journal- In Process).

Calderon F, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabushi R, Ginty DD, Kolodkin AL, and Tsai LH. An Autism Spectrum Disorder Susceptibility Gene, TAO2, is Important for Basal Dendrite Formation in the Neocortex. Nat Neurosci 2012 Jun 10;15(7):1022-31. doi: 10.1038/nn.3141. (PMC Journal- In Process).

Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Groves Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ. Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.Neuropharmacology. 2012 Jul 4. (In Press) (PMC Journal- In Process).

Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH. Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5. Neuron 2012 Aug 23;75(4):675-87. (PMC Journal- In Process).

Zhao WN, Cheng C, Theriault KM, Sheridan SD, Tsai LH, Haggarty SJ. A High-Throughput Screen for Wnt/β-Catenin Signaling Pathway Modulators in Human iPSC-Derived Neural Progenitors. J Biomol Screen. 2012 Aug 24. (In Press) (PMC Journal- In Process).

2011

Siegle JH, Carlen M, Meletis K, Tsai LH, Moore CI, Ritt J. Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:7529-32. PMCID: PMC 22256080.

Carlen M, Meletis K, Siegle JH, Cardin JA, Futai K, Vierling-Claassen D, Ruhlmann C, Jones SR, Deisseroth K, Sheng M, Moore CI, Tsai LH. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior Mol Psychiatry. 2012 May;17(5):537-48. doi: 10.1038/mp.2011.31. PMCID: PMC3335079.

Pinheiro EM, Xie Z, Norovich AL, Vidaki M, Tsai LH, Gertler FB. Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons. Nat Cell Biol. 2011 Jul 24;13(8):989-95. doi: 10.1038/ncb2292. PMCID: PMC3149714.

Buchman JJ, Durak O, Tsai LH. ASPM regulates Wnt signaling pathway activity in the developing brain.Genes Dev. 2011 Sep 15;25(18):1909-14. doi: 10.1101/gad.16830211. PMCID: PMC3185963.

Guan JS, Su SC, Gao J, Joseph N, Xie Z, Zhou Y, Durak O, Zhang L, Zhu JJ, Clauser KR, Carr S, Tsai LH. Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. PLos One 6(9): e25735. doi:10.1371/journal.pone.0025735 PMCID: PMC3184170.

Giusti-Rodríguez P, Gao J, Gräff J, Rei D, Soda T, Tsai LH. Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of beta-secretase (BACE1). J Neurosci. 2011 Nov 2;31(44):15751-6. PMCID: PMC3248793.

Kim J, Su SC, Wang H, Cheng AW, Cassady JP, Lodato MA, Lengner CJ, Chung C-Y, Dawlaty MM, Tsai LH, Jaenisch R. Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts. Cell Stem Cell. 2011 Nov 4;9(5):413-9. PMCID: PMC3210333.

Singh KK, DiRienzo G, Drane L, Mao Y, Flood Z, Madison J, Ferreira M, Bergen S, King C, Sklar P, Sive H, Tsai LH. Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development. Neuron. 2011 Nov 17;72(4):545-58. PMCID: PMC3387684.

Kwon E, Wang W, Tsai LH. Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C, and TCF4 as miR-137 targets. Mol Psychiatry. 2011 Dec 20. doi: 10.1038/mp.2011.170 (PMC Journal- In Process).

2010

Ge X, Frank CL, Calderon F, Tsai LH. Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron, 2010. Jan 28;65(2):191-203 PMCID: PMC2902371.

Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc. 2010 Feb;5(2):247-54 (PMC Journal- In Process).

Buchman JJ, Tseng HC, Zhou Y, Frank CL, Xie Z, and Tsai LH. Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex. Neuron, 2010 May;66: 386-402 (PMC Journal- In Process).

Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai LH, Yuan J. Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell. 2010. May 28;38(4):500-511. PMCID: PMC2888511.

Gao J, Wang WY, Mao YW, Gräff J, Guan JS, Pan L, Mak G, Kim D, Su SC, Tsai LH. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature. 2010 Aug. 26;466(7310):1105-9. PMCID: PMC2928875.

Singh KK, Ge X, Mao Y, Drane L, Meletis K, Samuels BA, Tsai LH. Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron. 2010 Jul 15;67(1):33-48. PMCID: PMC2938013.

De Anda CF, Meletis K, Ge X, Rei D, Tsai LH. Centrosome motility is essential for initial axon formation in the neocortex. J Neurosci 2010 Aug 4;30(31):10391-406. (PMC Journal- In Process).

Frank CL, Ge X, Xie Z, Zhou Y, Tsai LH. Control of ATF4 persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. J Biol Chem. 2010 Oct 22;285(43):33324-37. PMCID: PMC2963346.

Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci USA. 2010 Dec 14;107(50):21790-4.PMCID: PMC3003110.

2009

Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH. Disrupted in Schizophrenia 1 regulates neural progenitor proliferation via modulation of GSK3/-catenin signaling. Cell, 2009, Mar 20; 136(6): 1017-31 PMCID: PMC2704382.

Guan J-S, Haggarty SJ, Giacometti E, Dannenberg J-H, Joseph N, Gao J, Nieland TJF, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai, LH. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature, 2009 May 7; 459(7243): 55-60 (PMC Journal- In Process).

Cardin JA, Carlen M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature, 2009 Jun 4; 459(7247): 663-7 (PMC Journal- In Process).

Orlando LR, Ayala R, Kett LR, Curley AA, Duffner J, Bragg DC, Tsai LH, Dunah AW, Young AB. Phosphorylation of the homer-binding domain of group I metabotropic glutemate receptors by cyclin-dependent kinase 5. J Neurochem. 2009 Jul;110(2):557-69. (PMC Journal- In Process).

Davis DA, Wilson MH, Giraud J, Xie Z, Tseng HC, England C, Herscovitz H, Tsai LH, Delalle I. Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. PLoS Biol. 2009 Oct;7(10):e1000208. PMCID: PMC2748697.

2008

Calderon de Anda F, Gartner A, Tsai LH, Dotti, C. Pyramidal neuron polarity axis is defined at the bipolar stage. J Cell Sci, 2008 Jan 15;121(Pt 2):178-85.

Shim SY, Samuels BA, Wang J, Neumayer G, Belzil C, Ayala R, Shi Y, Shi Y, Tsai LH, Nguyen MD, Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth. J Biol Chem. 2008. May 2;283(18):12232-40 (PMC Journal- In Process).

Kim D, Frank C, Dobbin M, Tsunemoto R, Wu D, Peng P, Guan J, Lee B-H, Moy L, Gusti P, Broodie N, Mazitschek R, Delalle I, Haggarty S, Neve R, Lu Y, and Tsai LH. Deregulation of HDAC1 by p25/Cdk5 in neurodegeneration. Neuron, 2008, 60: 803-817 PMCID: PMC2912147.

Meyer DA, Richer E, Benkovic SA, Hayashi K, Kansy JW, Hale CF, Moy LY, Kim Y, O’Callaghan JP, Tsai LH, Greengard P, Nairn AC, Cowan CW, Miller DB, Antich P, Bibb JA. Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18561-6. PMCID: PMC2587606.

2007

Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai, LH. Recovery of learning and memory is associated with chromatin remodeling. Nature 2007, 447: 178-182.

Yip YP, Capriotti C, Drill E, Tsai LH, Yip J. Cdk5 Selectively Affects the Migration of Different Populations of Neurons in the Developing Spinal Cord. J Comp Neurol. 2007;503(2):297-307.

Kim D, Nguyen MD, Fischer A, Sananbenesi F, Dobbin MM, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigsrver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis. EMBO J 2007, 26: 3169-3179.

Sananbenesi F, Fischer A, Schrick C, Neve R, Radulovic J, Tsai LH. A Hippocampal Cdk5 Pathway Regulates Extinction of Contextual Fear. Nat Neurosci. 2007, 10(8): 1012-9.

Choe EA, Liao L, Zhou JY, Cheng D, Duong DM, Jin P, Tsai LH, Peng J. Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. J Neurosci. 2007, 27(35): 9503-12.

Xie Z, Moy L, Sanada K, Zhou Y, Buchman J, Tsai LH. Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neural Progenitor Pool. Neuron 2007, 56: 79-93.

Samuels, BA, Hsueh Y-P, Shu T, Liang H, Tseng H-C, Hong C-J, Su SC, Neve R, Yue, DT, Tsai, LH. Cdk5 promotes synapse formation by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 2007, 56: 823-837.

2006

ShuT., TsengH.C., ZhouY., FischerA., SternP., CoquelleF., ReinerO., Tsai L-H. Doublecortin-like Kinase Controls Neurogenesis by Regulating the Mitotic Spindle. Neuron 2006, 49:25-39.

Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai, L-H. p25/Cdk5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci 2006, 26: 10536-41.

2005

Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A. Mechanism of Cdk5/p25 binding by Cdk inhibitors. J Med Chem 2005, 48(3): 671-9.

Sanada K, Tsai LH. G protein beta/gamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. Cell 2005, 122: 119-131.

Tseng H-C, Ovaa H, Wei N, Ploegh H, Tsai LH. Phosphoproteomic analysis with a solid-phase capture-release-tag approach. Chemistry and Biology 2005, 12: 769-777.

Park, SK, Nguyen MD, Fischer A, Luke MP, Affar EB, Dieffenbach, PB, Tseng HC, Shi Y, Tsai LH. Par4 links dopamine signaling and depression. Cell 2005, 122: 275-287.

Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai LH. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron, 2005, 48: 825-838.

2004

Kao SC, Krichevsky AM, Kosic K, Tsai, LH. BACE1 suppression by RNA interference in primary cortical neurons. J Biol Chem 2004, 279: 1942-1949.

Hammond V, Tsai LH, Tan SS. Control of cortical neuron migration and layering: cell and non cell-autonomous effects of p35. J Neurosci 2004, 24: 576-87.

Tanaka T, Serneo FF, Tseng H-C, Kulkarni AB, Tsai LH, Gleeson JG. Cdk5 phosphorylation of doublecortin Ser297 regulates its effect on neuronal migration. Neuron 2004, 41:215-227.

Morabito MA, Sheng M, Tsai LH. The cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD95 in neurons. J Neurosci 2004, 24: 865-876.

Beffert U, Weeber E, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. J Neurosci2004, 24: 1897-1906.

Sanada K, Gupta A, Tsai LH. Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis. Neuron 2004, 22: 197-211.

Nguyen MD, Shu T, Sanada K, Lariviere RC, Tseng,HC, Park SK, Julien JP, Tsai LH. A NUDEL dependent mechanism of Neurofilament assembly regulates the integrity of CNS neurons. Nat Cell Biol 2004, 6: 597-608.

Shu T, Ayala R, Nguyen MD, Xie Z, Gleeson JG, Tsai LH. Ndel1 operates in a common pathway with Lis1 and cytoplasmic dynein to regulate cortical neuronal positioning. Neuron 2004, 44: 263-277.

Reviews Chapters & Editorials

Reviews Chapters & Editorials

2014

Madabhushi R, Pan L, Tsai LH. DNA Damage and its links to neurodegeneration. Neuron. 2014 July 16. doi: 10.1016/j.neuron.2014.06.034

2012

Wang W, Kwon EJ, Tsai LH. MicroRNAs in learning, memory, and neurological diseases. Learn Mem. 2012 Aug 16;19(9):359-68. doi: 10.1101/lm.026492.112. (PMC Journal- In Process).

Su SC, Tsai LH. DNA methylation in cognition comes of age. Nat Neurosci. 2012 Jul 26;15(8):1061-2. doi: 10.1038/nn.3169. (PMC Journal- In Process).

Mungenast AE, Tsai LH. Cognitive Function in Health and Disease: The Role of Epigenetic Mechanisms. Neurodegener Dis. 2012;10(1-4):191-4.

2011

Mungenast AE, Tsai L-H (2011) Addressing the complex etiology of Alzheimer’s disease: the role of p25/Cdk5. Future Neurology 6:481-496. (In Press) (PMC Journal- In Process).

Su SC, Tsai LH. Cyclin-Dependent Kinases in Brain Development and Disease. Annu Rev Cell Dev Biol. 2011 Nov 10;27:465-91 (PMC Journal- In Process).

Haggarty SJ, Tsai LH. Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiol Learn Mem. 2011 Jul;96(1):41-52. PMCID: PMC3188418.

De Anda FC, Tsai LH.Axon selection: From a polarized cytoplasm to a migrating neuron. Commun Integr Biol. 2011 May;4(3):304-7. PMCID: PMC3187892.

Gräff J, Kim D, Dobbin MM, Tsai L-H. Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiological Review 2011 Apr;91(2):603-49. (PMC Journal- In Process).

Marín O, Valiente M, Ge X, Tsai LH. Guiding neuronal cell migrations. Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a001834. PMCID: PMC2828271.

Gräff J, Tsai LH. Cognitive Enhancement: A molecular memory booster. Nature. 2011 Jan 27; 469:474-475. (PMC Journal- In Process).

2010

Fischer A, Sananbenesi F, Mungenast A, Tsai LH. Targeting the correct HDAC(s) to treat cognitive disorders. Trends Pharmacol Sci. 2010 Dec;31(12):605-17. (PMC Journal- In Process).

Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai L-H. Amyloid-independent mechanisms in Alzheimer’s disease pathogenesis. J Neurosci. 2010 Nov 10;30(45):14946-54. (PMC Journal- In Process).

Singh K, Tsai L-H. MicroTUB(B3)ules and Brain Development. Cell, 2010, Jan; 140: 7-9. Marín O, Valiente M, Ge X, Tsai LH. Guiding neuronal cell migrations.Cold Spring Harb Perspect Biol. 2010 Feb; 2(2):a001834. PMCID: PMC2828271

2009

Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ. Cyclin-dependent kinsases: a family portrait. Nat Cell Biol. 2009 Nov;11(11):1275-6. PMCID: PMC2914104

Kim D, Tsai L-H. Linking cell cycle reentry and DNA damage in neurodegeneration. Ann NY Acad Sci. 2009 Jul;1170:674-9. (PMC Journal- In Process).

Kim D, Tsai L-H. Bridging physiology and pathology in AD. Cell. 2009, 137: 997-1000. (PMC Journal- In Process).

Frank CL, Tsai L-H. Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. Neuron. 2009 May 14, 62(3): 312-326. PMCID: PMC2757047

2008

Fischer A, Tsai L-H. Cyclin dependent kinase 5 (Cdk5): linking synaptic plasticity and neurodegeneration. In Cyclin dependent kinase 5 (Cdk5). Eds. Nancy Ip, & Li-Huei Tsai, Springer Science and Business Media LLC, New York, 2008; 261-282.

Buchman JJ, Tsai L-H. Putting a notch in our understanding of nuclear migration. Cell. 2008, 134: 912-4.

Samuels BA, Tsai L-H. Neuronal motility and structure: Cdk5 pathways. In Larry R. Squire, Editor-in-Chief, Encyclopedia of Neuroscience, Academic Press, Oxford, 2008.

2007

Buchman JJ, Tsai L-H. Spindle regulation in neural precursors of flies and mammals. Nat Rev Neurosci. 2007, 8: 89-100.

Ayala R, Shu T, Tsai L-H. Trekking across the brain: the journey of neuronal migration. Cell 2007; 128: 29-43.

2006

Xie Z, Samuels BA, Tsai L-H. Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling—a hypothesis on neuronal migration. Cereb Cortex. 2006: Suppl 1: i64-8.

2005

Tsai L-H, Gleeson JG. Nucleokinesis in neuronal migration. Neuron 2005; 46: 383-388.

2004

Samuels BA, Tsai L-H. Nucleokinesis illuminated. Nat Neurosci 2004; 7:1169-1170.

Cruz JC, Tsai L-H. Cdk5 deregulation in the pathogenesis of Alzheimer’s disease. Trends Mol Med. 2004; 10: 452-8.

Cruz JC, Tsai L-H. A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. Curr Opin Neurobiol. 2004; 14: 390-394.

Tsai L-H, Lee MS, Cruz JC. Cdk5, a therapeutic target for Alzheimer’s disease? Biochim Biophys Acta. 2004; 1697: 137-142.

Xie Z, Tsai L-H. Cdk5 phosphorylation of FAK regulates centrosome-associated microtubules and neuronal migration. Cell Cycle. 2004; 3: 108-110.

2003

Gupta A, Tsai L-H. Cyclin-dependent kinase 5 and neuronal migration in the neocortex. Neurosignals. 2003 Sep-Oct;12(4-5):173-9.

Patzke H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai LH. Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene. J Neurosci. 2003 Apr 1;23(7):2769-78.

Samuels BA, Tsai L-H. Cdk5 is a dynamo at the synapse. Nat Cell Biol. 2003; 5: 689-690.

Lee, M-S, Tsai L-H. Cdk5: One of the links between senile plaques and neurofibrillary tangles? J Alzh Dis. 2003; 5:127-137.

2002

Gupta A, Tsai L-H, Wynshaw-Boris A. Life is a journey: a genetic look at neocortical development. Nat. Rev Gene, 2002; 3:342-55.

Patzke H, Tsai L-H. Cdk5 sinks into ALS. Trends Neurosci. 2002; 25:8-10.

Smith DS, Tsai L-H. Cdk5 behind the wheel: a role in trafficking and transport. Trends Cell Biol 2002; 12: 28-36.

2001

Dhavan R, Tsai L-H. A decade of Cdk5. Nat Rev Mol Cell Biol. 2001; 2: 749-759.

Smith DS, Greer PL, Tsai L-H. Cdk5 on the brain. Cell Growth Differ 2001;12:277-283.

Gupta A, Tsai L-H. A kinase to dampen the effects of cocaine? Science 2001;292:236-237.

Lee M-S, Tsai L-H. Cdk5 at the junction. News and Views, Nat Neurosci 2001; 4: pp340-342.

2000

Nikolic M, Tsai L-H. Activity and regulation of p35/Cdk5 kinase complex. Methods Enzymol. 2000;325:200-13.

Kwon YT, Tsai L-H. The role of the p35/Cdk5 kinase in cortical development. Results Probl Cell Differ. 2000;30:241-53.

1998

Tsai L-H. Stuck on the ECM. Trends Cell Biol. 1998 Jul;8(7):292-5.

1994

Caviness VS Jr, Takahashi T, Miyama S, Tsai L-H. Cytogenesis in the developing mouse neocortex. In: Brain lesions in the newborn. Alfred Benzon Symposium 1994;37:25-42.

1992

Stillman and J. Watson (eds), Cold Spring Harbor Laboratory Press. Faha B, Meyerson M, Tsai L-H. Adenovirus E1A targets one of two cyclin A-kinase complexes. Pezcoller Foundation Symposium 1992; 3:107-30.

1991

Meyerson M, Faha B, Su LK, Harlow E, Tsai L-H. The cyclin-dependent kinase family. In The Cell Cycle, Cold Spring Harbor Symposium on Quantitation Biology, 1991 56:177-186. D. Beach, B.

系所成員 系所師資 專任教授 蔡立慧 Tsai, Li-Huei